Not with the old client because Shockwave doesn't like resizing very much, I tried getting it working a few times but there was too much wrong to do it (I fixed the problems the client had with it, but there was stuff that shockwave did that made it unusable). You can resize the new client fine though, if you can wait.
There is one way that works though, if you use Windows and increase the font size (there's a checkbox, i can't remember where to find it but the values are something like 100%, 150% and 200%), it increases the size of the vmk window... it also does it for other things, it's not the same as resolution though. But obviously that's not ideal and unless you don't mind having that active all the time then you might as well change your resolution, try it out though. The last option would be using a virtual machine which is a bit over the top I think.