Shrunken Ned's non-stop chatter in Jungle Cruise. No, you disembodied git, I can steer this thing just fine, it's the crocodile that keeps popping up right in front of me.
In Castle Fireworks, when you're following a particular shell just waiting for that twinkle, and another one flies up in front of it and messes up your timing.
Typing a sentence just one or two letters over the length of the chat field.